通过移植长期保存RCS大鼠皮质依赖的视觉功能。

Long-term preservation of cortically dependent visual function in RCS rats by transplantation.

作者信息

Coffey P J, Girman S, Wang S M, Hetherington L, Keegan D J, Adamson P, Greenwood J, Lund R D

机构信息

Department of Psychology, University of Sheffield, Western Bank, Sheffield, S10 2TP, UK.

出版信息

Nat Neurosci. 2002 Jan;5(1):53-6. doi: 10.1038/nn782.

DOI:10.1038/nn782

PMID:11753416

Abstract

Cell transplantation is one way of limiting the progress of retinal degeneration in animal models of blinding diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD). Here we transplanted a human retinal pigment epithelial (RPE) cell line into the subretinal space of one such model, the Royal College of Surgeons (RCS) rat, and showed, using head tracking to moving stripes and pattern discrimination in conjunction with single-unit cortical physiology, that cortically mediated vision can be preserved with this treatment.

摘要

细胞移植是在诸如色素性视网膜炎（RP）和年龄相关性黄斑变性（AMD）等致盲疾病的动物模型中限制视网膜变性进展的一种方法。在此，我们将一种人视网膜色素上皮（RPE）细胞系移植到其中一种模型——皇家外科学院（RCS）大鼠的视网膜下间隙，并通过使用头部跟踪移动条纹以及结合单单位皮质生理学的模式辨别方法，证明这种治疗可以保留皮质介导的视觉。