质子释放作为突触前功能的调节剂。

Proton release as a modulator of presynaptic function.

作者信息

Traynelis S F, Chesler M

机构信息

Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA.

出版信息

Neuron. 2001 Dec 20;32(6):960-2. doi: 10.1016/s0896-6273(01)00549-9.

DOI:10.1016/s0896-6273(01)00549-9

PMID:11754826

Abstract

In this issue of Neuron, DeVries (2001) describes experiments suggesting that acidification of the synaptic cleft can reduce Ca2+ channel activity and thereby act as a brake on tonic synaptic release of glutamate from cone cells. This work hints at a potentially important new facet to the regulation of synaptic transmission.

摘要

在本期《神经元》杂志中，德弗里斯（2001年）描述了一些实验，这些实验表明突触间隙的酸化会降低钙离子通道活性，从而对锥体细胞谷氨酸的强直性突触释放起到制动作用。这项研究暗示了突触传递调节中一个潜在的重要新方面。