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Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.
J Neurosci. 2002 Jan 1;22(1):156-66. doi: 10.1523/JNEUROSCI.22-01-00156.2002.
3
Neurotrophin receptor interacting factor (NRIF) is an essential mediator of apoptotic signaling by the p75 neurotrophin receptor.
J Biol Chem. 2005 Apr 8;280(14):13801-8. doi: 10.1074/jbc.M410435200. Epub 2005 Jan 24.
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Eiger-induced cell death relies on Rac1-dependent endocytosis.
Cell Death Dis. 2016 Apr 7;7(4):e2181. doi: 10.1038/cddis.2016.80.
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Neurotrophin signaling through the p75 receptor is deficient in traf6-/- mice.
J Neurosci. 2004 Nov 17;24(46):10521-9. doi: 10.1523/JNEUROSCI.1390-04.2004.
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Rac and Cdc42-dependent regulation of c-Jun N-terminal kinases by the delta-opioid receptor.
J Neurochem. 2003 Feb;84(3):503-13. doi: 10.1046/j.1471-4159.2003.01535.x.
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Evidence for a role of mixed lineage kinases in neuronal apoptosis.
J Neurosci. 2001 Jul 15;21(14):4949-57. doi: 10.1523/JNEUROSCI.21-14-04949.2001.

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Nerve Growth Factor and Autoimmune Diseases.
Curr Issues Mol Biol. 2023 Nov 10;45(11):8950-8973. doi: 10.3390/cimb45110562.
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Genetic and Pharmacological Modulation of P75 Neurotrophin Receptor Attenuate Brain Damage After Ischemic Stroke in Mice.
Mol Neurobiol. 2024 Jan;61(1):276-293. doi: 10.1007/s12035-023-03550-1. Epub 2023 Aug 22.
6
Genetic deletion of c-Jun amino-terminal kinase 3 (JNK3) modestly increases disease severity in a mouse model of multiple sclerosis.
J Neuroimmunol. 2023 Sep 15;382:578152. doi: 10.1016/j.jneuroim.2023.578152. Epub 2023 Jul 12.
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The Role of Neurotrophin Signaling in Age-Related Cognitive Decline and Cognitive Diseases.
Int J Mol Sci. 2022 Jul 13;23(14):7726. doi: 10.3390/ijms23147726.

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1
RhoA inhibits the nerve growth factor-induced Rac1 activation through Rho-associated kinase-dependent pathway.
J Biol Chem. 2001 Jun 1;276(22):18977-83. doi: 10.1074/jbc.M100254200. Epub 2001 Mar 15.
4
p75 is important for axon growth and schwann cell migration during development.
J Neurosci. 2000 Oct 15;20(20):7706-15. doi: 10.1523/JNEUROSCI.20-20-07706.2000.
5
Dual roles for c-Jun N-terminal kinase in developmental and stress responses in cerebellar granule neurons.
J Neurosci. 2000 Oct 15;20(20):7602-13. doi: 10.1523/JNEUROSCI.20-20-07602.2000.
8
NG2-positive oligodendrocyte progenitor cells in adult human brain and multiple sclerosis lesions.
J Neurosci. 2000 Sep 1;20(17):6404-12. doi: 10.1523/JNEUROSCI.20-17-06404.2000.

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