Hoogenraad N J, Ryan M T
Department of Biochemistry, La Trobe University, Melbourne, Australia.
IUBMB Life. 2001 Jun;51(6):345-50. doi: 10.1080/152165401753366096.
The translocase of the outer mitochondrial membrane (TOM) is composed of receptors, a channel protein, and its modulators that function together to import proteins into mitochondria. Although the import pathway of proteins directed to the mitochondrial matrix has been well characterized, recent studies into the import pathway taken by proteins into the other submitochondrial compartments have broadened our understanding into the way the TOM machinery recognizes, interacts, and translocates proteins.
线粒体外膜转位酶(TOM)由受体、通道蛋白及其调节剂组成,它们共同发挥作用,将蛋白质导入线粒体。尽管靶向线粒体基质的蛋白质的导入途径已得到充分表征,但最近对蛋白质进入其他亚线粒体区室所采用的导入途径的研究,拓宽了我们对TOM机制识别、相互作用和转运蛋白质方式的理解。