Manonai J, Theppisai U, Chittacharoen A
Department of Obstetrics and Gynaecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
J Med Assoc Thai. 2001 Jul;84(7):1015-20.
To evaluate the effects of a 17 beta-estradiol vaginal tablet on urogenital symptoms, vaginal pH, vaginal cytology, endometrial thickness, and plasma estradiol level in postmenopausal women with urogenital symptoms.
Twenty-seven postmenopausal women with urogenital symptoms received 25 microg of a 17 beta-estradiol tablet intravaginally daily for the first 2 weeks, followed by 10 weeks of twice a week dosage. The results of urogenital symptoms, vaginal pH, vaginal cytology, endometrial thickness, and plasma estradiol level were analysed.
The urogenital symptoms improved significantly in all women. The mean vaginal pH was significantly decreased. The vaginal cytology showed estrogenic effect on the karyopyknotic index and the maturation value. There was no significant difference in endometrial thickness and level of plasma estradiol before and after treatment. There was one case of vaginal bleeding from endometrial proliferation.
Local vaginal treatment of 17 beta-estradiol (25 microg) had a positive effect on the urogenital symptoms, vaginal pH, and vaginal cytology. No elevation of plasma estradiol level was detected after treatment.
评估17β-雌二醇阴道片对有泌尿生殖系统症状的绝经后女性的泌尿生殖系统症状、阴道pH值、阴道细胞学、子宫内膜厚度及血浆雌二醇水平的影响。
27例有泌尿生殖系统症状的绝经后女性，在最初2周每天阴道内给予25μg 17β-雌二醇片，随后10周每周给药两次。分析泌尿生殖系统症状、阴道pH值、阴道细胞学、子宫内膜厚度及血浆雌二醇水平的结果。
所有女性的泌尿生殖系统症状均显著改善。平均阴道pH值显著降低。阴道细胞学显示对核固缩指数和成熟值有雌激素作用。治疗前后子宫内膜厚度和血浆雌二醇水平无显著差异。有1例因子宫内膜增生出现阴道出血。
局部阴道给予17β-雌二醇（25μg）对泌尿生殖系统症状、阴道pH值和阴道细胞学有积极作用。治疗后未检测到血浆雌二醇水平升高。
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