传染性海绵状脑病：疫苗问题。

Transmissible spongiform encephalopathies: vaccine issues.

作者信息

Cashman N R

机构信息

Department of Medicine (Neurology), Center for Research in Neurodegenerative Diseases and Sunnybrook and Women's College Health Sciences Center, University of Toronto, Ontario, Canada.

出版信息

Dev Biol (Basel). 2001;106:455-9; discussion 460-1, 465-75.

PMID:11761262

Abstract

The recent emergence of bovine spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob Disease (vCJD) suggests that transmissible spongiform encephalopathies (TSEs) pose an ongoing threat to human and animal health. To avoid iatrogenic transmission of TSEs in vaccines, strategies must be developed to obviate TSE agent infectivity in cellular substrates, cell culture media components and enzymes, and excipients, and to validate the safety of these components and field vaccines efficiently

摘要

最近牛海绵状脑病（BSE）和变异型克雅氏病（vCJD）的出现表明，传染性海绵状脑病（TSEs）对人类和动物健康构成持续威胁。为避免疫苗中TSEs的医源性传播，必须制定策略以消除细胞基质、细胞培养基成分、酶和辅料中的TSE病原体感染性，并有效验证这些成分和现场疫苗的安全性。