Anburajan M, Rethinasabapathi C, Korath M P, Ponnappa B G, Kumar K S, Panicker T M, Govindan A, Jagadeesan G N
Department of Medical Physics, KJ Research Foundation, KJ Hospital, Research and PG Training Centre, Chennai, India.
J Assoc Physicians India. 2001 Apr;49:442-5.
i) To collect normative data for proximal femur bone mineral density (BMD) in South Indian women using dual energy X-ray absorptiometry (DXA) and ii) to study the rate and significance of hip bone mineral loss with advancing age in this population.
Forty five women, whose age ranged from 16 to 84 years were studied. This sample was drawn randomly from general medical practice at KJ Hospital, Chennai, South India during November, 1997 to April, 1998. Of these 45 cases, 21 were pre-menopausal (mean +/- SD age = 30.9+/-8.8 years) and 24 post-menopausal (mean +/- SD age = 62.1+/-11.0 years). Subjects with secondary bone diseases were excluded. Also excluded were those taking any drugs known to affect calcium metabolism e.g., thiazide diuretics, oestrogen and calcium. Subjects were divided into seven decadal age groups from 15-24 years to 75-84 years. BMD of the right proximal femur was evaluated using a QDR-1000 DXA bone densitometer (Hologic Inc., Waltham, Massachusetts, USA). Data analysis was done with SPSS/PC statistical software package.
Linear regression analysis showed significant (p < 0.001) negative correlations between all hip BMD variables at different regions of interest and patient's age. Relative to that at 30 years of age, rates of BMD loss in the neck of femur, trochanter, intertrochanter, total hip and Ward's triangle were 0.68%, 0.65%, 0.58%, 0.61% and 1.05% per annum respectively. Over the age of 65 years, the above mentioned regions BMD decreased by 0.91%, 0.84%, 0.72%, 0.78% and 1.66% per annum respectively.
Normative data for proximal femur BMD in South India women have been evaluated and it may prove useful for diagnosing osteoporosis in the women of South India.
i）使用双能X线吸收法（DXA）收集南印度女性近端股骨骨密度（BMD）的标准数据，ii）研究该人群中随着年龄增长髋部骨量丢失的速率及意义。
对45名年龄在16至84岁之间的女性进行研究。该样本于1997年11月至1998年4月期间从印度南部金奈KJ医院的普通医疗实践中随机抽取。在这45例中，21例为绝经前女性（平均年龄±标准差 = 30.9±8.8岁），24例为绝经后女性（平均年龄±标准差 = 62.1±11.0岁）。排除患有继发性骨病的受试者。还排除了正在服用任何已知会影响钙代谢的药物的受试者，例如噻嗪类利尿剂、雌激素和钙剂。受试者被分为从15 - 24岁到75 - 84岁的七个十年年龄组。使用QDR - 1000 DXA骨密度仪（美国马萨诸塞州沃尔瑟姆市Hologic公司）评估右侧近端股骨的骨密度。数据分析使用SPSS/PC统计软件包进行。
线性回归分析显示，不同感兴趣区域的所有髋部骨密度变量与患者年龄之间存在显著（p < 0.001）负相关。相对于30岁时的骨密度，股骨颈、大转子、转子间、全髋和沃德三角区的骨密度每年丢失率分别为0.68%、0.65%、0.58%、0.61%和1.05%。65岁以上时，上述区域的骨密度每年分别下降0.91%、0.84%、0.72%、0.78%和1.66%。
已评估了南印度女性近端股骨骨密度的标准数据，这可能对诊断南印度女性的骨质疏松症有用。
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