Halloran B G, Lilly M P, Cohn E J, Benjamin M E, Flinn W R
Division of Vascular Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.
Ann Vasc Surg. 2001 Nov;15(6):634-43. doi: 10.1007/s10016-001-0090-z.
Over an 8-year period, we performed 93 lower extremity bypasses using complex autologous conduits, which included (1) contralateral greater saphenous vein (GSV), (2) composite GSV, (3) superficial femoral vein, (4) lesser saphenous vein, (5) cephalic or basilic veins, and (6) composite-sequential (PTFE and vein) grafts. These grafts represented 16% of all infrainguinal bypasses during this period, and all grafts were performed to treat limb-threatening ischemia. Survival, patency, and limb salvage were examined by the life-table method. Primary graft patency was 46 and 38% at 3 and 5 years. Assisted-primary patency was 62 and 59%, and secondary graft patency rates were 68 and 64% at 3 and 5 years. Twenty-nine bypasses (31%) required revision to restore or maintain patency. The 3-year limb salvage rate was significantly better when revision was performed for graft stenosis than for graft thrombosis (90% vs. 46%, p < 0.05). Overall limb salvage rate was 73% at 5 years. The mortality rate was 5.4% and the 5-year survival was 51%. Complex autologous tibial bypasses provided acceptable long-term limb salvage in patients with severe ischemia and inadequate ipsilateral GSV. The increased operating time and complexity required did not produce prohibitive operative risks. Postoperative graft surveillance in these complex vein bypasses allowed revision in many cases before graft occlusion occurred and significantly improved long-term limb salvage.
在8年期间,我们使用复杂的自体血管进行了93例下肢搭桥手术,这些自体血管包括:(1) 对侧大隐静脉(GSV);(2) 复合大隐静脉;(3) 股浅静脉;(4) 小隐静脉;(5) 头静脉或贵要静脉;以及(6) 复合序贯(聚四氟乙烯和静脉)移植物。这些移植物占该时期所有腹股沟下搭桥手术的16%,所有手术均用于治疗威胁肢体的缺血。通过寿命表法检查生存率、通畅率和肢体挽救情况。3年和5年时的原发性移植物通畅率分别为46%和38%。辅助原发性通畅率分别为62%和59%,3年和5年时的继发性移植物通畅率分别为68%和64%。29例搭桥手术(31%)需要进行翻修以恢复或维持通畅。因移植物狭窄进行翻修时的3年肢体挽救率显著高于因移植物血栓形成进行翻修时的情况(90%对46%,p<0.05)。5年时的总体肢体挽救率为73%。死亡率为5.4%,5年生存率为51%。复杂的自体胫骨搭桥手术为患有严重缺血且同侧大隐静脉不适用的患者提供了可接受的长期肢体挽救效果。所需的手术时间和复杂性增加并未产生过高的手术风险。对这些复杂静脉搭桥手术进行术后移植物监测,使得在许多病例中能够在移植物闭塞前进行翻修,并显著提高了长期肢体挽救率。