生物统计学家在癌症研究中的作用。

The role of the biostatistician in cancer research.

作者信息

Gehan E A

机构信息

Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20007, USA.

出版信息

Biomed Pharmacother. 2001 Nov;55(9-10):502-9. doi: 10.1016/s0753-3322(01)00134-2.

DOI:10.1016/s0753-3322(01)00134-2

PMID:11769956

Abstract

This article considers triumphs and challenges for biostatisticians working in oncology at the beginning of the 21st century. The impact of three major articles in biostatistics in the 20th century is considered: Cornfield's 1951 paper on estimating comparative rates from clinical data; Mantel and Haenszel's 1959 paper on obtaining summary measures of relative risk, adjusting for stratification factors in epidemiological studies; and D. R. Cox's 1972 paper, which developed the proportional hazards model for evaluating the effect of covariates on survival time outcomes. Biostatistical challenges for the 21st century are considered for the areas of clinical trials, survival analysis, and statistical genetics.

摘要

本文探讨了21世纪初肿瘤学领域生物统计学家所取得的成就与面临的挑战。文中回顾了20世纪生物统计学领域三篇重要论文的影响：1951年科恩菲尔德关于从临床数据估计比较率的论文；1959年曼特尔和海恩泽尔关于获取相对风险汇总测量值、针对流行病学研究中的分层因素进行调整的论文；以及1972年D. R. 考克斯的论文，该论文提出了用于评估协变量对生存时间结果影响的比例风险模型。文章还探讨了21世纪临床试验、生存分析和统计遗传学领域的生物统计挑战。