[The change in the plasma contents of adrenomedullin and endothelin in burn patients during early postburn stage].

OBJECTIVE

To observe the change in the plasma contents of adrenomedullin (ADM) and endothelin (ET) in burn patients, so as for us to explore their roles in the pathogenesis in the physiological disturbance in burn patients.

METHODS

The plasma concentrations of ADM and ET were determined at 6, 12, 24 and 48 postburn hours (PBHs) in 40 burn patients with radioimmunoassay (RIA) and compared with those of 25 healthy people.

RESULTS

The postburn plasma levels of ADM and ET in burn patients increased immediately after injury, and they were positively correlated to burn area. The plasma ADM reached peak level at 12 PBHs and decreased thereafter, but remained at higher level than that in healthy people at 48 PBHs (P < 0.01). Plasma ET increased to top level at 6 PBH and decreased thereafter. But it remained at high level at 48 PBHs in severe burn patients (burned area larger than 45% TBSA) (P < 0.05 approximately 0.01). The plasma levels of ET and ADM increased proportionally and their ratio was close to that in normal control, but it decreased obviously after 6 PBH in all groups (P < 0.01).

CONCLUSION

There were evident postburn changes in plasma ADM and ET contents, and the results implied that ADM and ET played some roles in the development of postburn physiological disturbance.