Delyukov A, Gorgo Y, Cornélissen G, Otsuka K, Halberg F
Biological Faculty, Taras Shevchenko University, Kiev, Ukraine.
Biomed Pharmacother. 2001;55 Suppl 1:84s-92s. doi: 10.1016/s0753-3322(01)90009-5.
To study the interactions among the natural physical environmental cycles and human infradian components of heart rate (HR) and HR variability (HRV), a healthy 49-year-old man in Kiev, who had monitored his electrocardiogram (ECG) around the clock earlier for 50 days, added at a later date with the same ambulatorily wearable device, a record of 70 days. The mean value of the R-R intervals (R-R), their standard deviation (SDNN) and other HRV endpoints, computed over consecutive 5-min intervals, served as markers of the subject's functional associations with the amplitude of fluctuations in atmospheric pressure (FAP) and the planetary Kp index of geomagnetic disturbance. About-weekly and half-weekly cycles in HRV endpoints indicate a reduction in physiological 'preparedness', here described as 'dynamics', of the subject investigated on Saturdays and Sundays and a sharp increase in 'dynamics' on Mondays. The waveform of the weekly oscillation seemed to be influenced by ambient air temperature and FAP. On Mondays, an FAP amplification or a temperature rise was accompanied by a significant decrease in R-R and SDNN, indicating an aggravation of a 'Monday effect' in physiological 'dynamics'. HRV endpoints also revealed about-5-day and about-12-day cyclic components similar to those found in FAP. The infradian pattern in a 70-day record differed from one found earlier in a 50-day record of the same subject. Changes in the natural physical environment (past as well as present), especially in air temperature and FAP, likely influence(d) if not synchronize(d) the amplitude and waveform of infradian weekly and half-weekly physiological cycles. Some of these infradians, their wobbly nature notwithstanding, may have been built into our temporal make-up by an evolutionary integration of life in the non-stationary quasi-periodic natural physical environment, which continues to contribute to variability.
为了研究自然物理环境周期与人类心率(HR)和心率变异性(HRV)的亚日节律成分之间的相互作用,基辅一名49岁的健康男子,他此前曾使用可穿戴设备全天候监测心电图(ECG)达50天,之后又使用同一设备记录了70天。连续5分钟间隔计算的R-R间期(R-R)平均值、其标准差(SDNN)和其他HRV终点指标,作为该受试者与大气压力波动幅度(FAP)和地磁扰动行星Kp指数功能关联的标志物。HRV终点指标中约每周和每半周的周期表明,在周六和周日接受调查的受试者生理“准备状态”(此处称为“动态变化”)降低,而在周一“动态变化”急剧增加。每周振荡的波形似乎受环境气温和FAP影响。在周一,FAP放大或气温上升伴随着R-R和SDNN显著下降,表明生理“动态变化”中“周一效应”加剧。HRV终点指标还揭示了约5天和约12天的周期成分,与FAP中发现的类似。70天记录中的亚日节律模式与该受试者早期50天记录中发现的不同。自然物理环境(过去和现在)的变化,尤其是气温和FAP的变化,即使没有同步,也可能影响亚日节律每周和每半周生理周期的幅度和波形。尽管其中一些亚日节律具有不稳定的性质,但它们可能通过在非平稳准周期自然物理环境中生命的进化整合而融入我们的时间构成中,这种环境继续导致变异性。