Hu W, Chen M, Luo F
Cancer Center, Sun Yet-sen University of Medical Sciences, Guangzhou 510060, China.
Zhonghua Zhong Liu Za Zhi. 2001 May;23(3):240-3.
To analyze the factors affecting prognosis of patients with primary non-Hodgkin's lymphomas (NHL) of the nasal cavity.
From Jan. 1968 to Dec. 1997, a total of 71 patients with stage IE(Ann Arbor staging system, 1971) primary non-Hodgkin's lymphomas of the nasal cavity were treated in the Tumor Hospital of Sun Yat-sen University of Medical Sciences. In 37 of the 71 patients, the lesions were limited in the nasal cavity (limited IE), and in 34, the lesions were locally extended involving the adjacent structures (extended IE) Forty-four patients were treated with radiotherapy and 27 with radiotherapy plus chemotherapy. Survival analysis was done by the Kaplan-Meier method, and multivariate analysis was carried out using Cox proportional hazard model.
The 5- and 10-year survival rate was 71.9% and 59.7% respectively in patients who had complete response to radiotherapy. The 5- and 10-year survival rate was both 13.9% in patients who had residual tumors after treatment. The 5- and 10-year survival rate was 69.8% and 56.7% in patients with limited IE lesions, but 40.7% and 35.6% in those with extended IE lesions. The prognosis was better in younger (< 44 years) than in older patients. The 10-year survival rate of patients received radiotherapy alone and those combined with chemotherapy was 52.0% and 75.0% respectively for limited IE as compared to 37.6% and 45.0% for extended IE. B symptoms did not significantly affect clinical outcome. Multivariate analysis showed that the immediate response to radiotherapy, invasion of the primary tumor outside of nasal cavity and patients' age were independent prognostic factors.
Radiotherapy is the main treatment method for stage IE non-Hodgkin's lymphoma of the nasal cavity. Addition of chemotherapy can improve long-term survival. The local tumor response to radiotherapy, clinical staging and age of patients have significant influence on patients' prognosis.
分析影响鼻腔原发性非霍奇金淋巴瘤（NHL）患者预后的因素。
1968年1月至1997年12月，中山大学肿瘤防治中心共收治71例鼻腔原发性非霍奇金淋巴瘤患者，采用Ann Arbor分期系统（1971年），均为IE期。其中37例病变局限于鼻腔（局限IE期），34例病变局部扩展累及相邻结构（扩展IE期）。44例患者接受单纯放疗，27例患者接受放疗联合化疗。采用Kaplan-Meier法进行生存分析，并用Cox比例风险模型进行多因素分析。
放疗后完全缓解患者的5年和10年生存率分别为71.9%和59.7%。治疗后有残留肿瘤患者的5年和10年生存率均为13.9%。局限IE期病变患者的5年和10年生存率分别为69.8%和56.7%，而扩展IE期病变患者分别为40.7%和35.6%。年轻患者（<44岁）的预后优于老年患者。局限IE期患者单纯放疗和放疗联合化疗的10年生存率分别为52.0%和75.0%，扩展IE期分别为37.6%和45.0%。B症状对临床结局无显著影响。多因素分析显示，放疗的近期反应、原发肿瘤鼻腔外侵犯及患者年龄是独立的预后因素。
放疗是鼻腔IE期非霍奇金淋巴瘤的主要治疗方法。加用化疗可提高长期生存率。放疗后局部肿瘤反应、临床分期及患者年龄对患者预后有显著影响。
Zotero 插件