Linkage mapping of the mouse nephrosis (nep) gene to chromosome 15.
作者信息
Okamoto M, Yokoi N, Serikawa T, Tajima M, Kurosawa T
机构信息
The Institute of Experimental Animal Sciences, Osaka University Medical School, Suita, Japan.
出版信息
J Vet Med Sci. 2001 Dec;63(12):1347-50. doi: 10.1292/jvms.63.1347.
PMID:11789617
Abstract
ICGN is a partially inbred strain of mice with nephrotic syndrome caused by spontaneous glomerular lesion. It has been reported that the albuminuria in ICGN mouse was controlled by at least a single autosomal recessive gene (nep). In this study, we mapped the nep locus by linkage analysis of backcross progeny between ICGN and MSM mice using DNA pooling method. The linkage analysis revealed that the nep locus was localized on the distal part of chromosome 15.
摘要
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