非色素睫状上皮腺癌：两例报告及免疫组化结果

Adenocarcinoma of the nonpigmented ciliary epithelium: report of two cases with immunohistochemical findings.

作者信息

Terasaki H, Nagasaka T, Arai M, Harada T, Miyake Y

机构信息

Department of Ophthalmology, Nagoya University School of Medicine, Japan.

出版信息

Graefes Arch Clin Exp Ophthalmol. 2001 Nov;239(11):876-81. doi: 10.1007/s004170100353.

DOI:10.1007/s004170100353

PMID:11789870

Abstract

BACKGROUND

Acquired neoplasms arising from the nonpigmented ciliary epithelium (NPCE) are much less common than uveal melanocytic proliferations. We report two cases of acquired neoplasms arising from the NPCE with immunohistochemical findings.

METHODS

Case reports.

RESULTS AND CONCLUSIONS

Patient 1 was a 39-year-old man who presented with a pigmented mass behind the iris and secondary exudative retinal detachment. The eye also developed neovascular glaucoma. Patient 2 was a 44-year-old woman with a ciliary body mass but without symptoms. Both of these tumors were classified histologically as low-grade adenocarcinomas of the NPCE from specimens successfully removed by iridocyclectomy. Immunohistochemical findings confirmed the origin of the tumor cells; however, some changes in the immunoreactivity to cytokeratin AE1 and epithelial membrane antigen were found.

摘要

背景

起源于无色素睫状体上皮（NPCE）的后天性肿瘤比葡萄膜黑素细胞增生症少见得多。我们报告两例起源于NPCE的后天性肿瘤的免疫组化结果。

方法

病例报告。

结果与结论

患者1为39岁男性，表现为虹膜后色素性肿物及继发性渗出性视网膜脱离。该眼还并发新生血管性青光眼。患者2为44岁女性，有睫状体肿物但无症状。通过虹膜睫状体切除术成功切除的标本经组织学检查，这两个肿瘤均被分类为NPCE的低级别腺癌。免疫组化结果证实了肿瘤细胞的起源；然而，发现细胞角蛋白AE1和上皮膜抗原的免疫反应性有一些变化。