ERM蛋白与NF2肿瘤抑制因子：皮质肌动蛋白组织和细胞生长信号传导的阴阳两面

ERM proteins and NF2 tumor suppressor: the Yin and Yang of cortical actin organization and cell growth signaling.

作者信息

Gautreau Alexis, Louvard Daniel, Arpin Monique

机构信息

UMR 144 CNRS/Institut Curie, 26 rue d'Ulm, 75248 Cedex 05, Paris, France.

出版信息

Curr Opin Cell Biol. 2002 Feb;14(1):104-9. doi: 10.1016/s0955-0674(01)00300-3.

DOI:10.1016/s0955-0674(01)00300-3

PMID:11792551

Abstract

The ERM (ezrin, radixin and moesin) family of proteins are linkers that tether actin microfilaments to the plasma membrane. Merlin, the NF2 tumor suppressor gene product, is highly homologous to ERM proteins. In ERM proteins and merlin, interdomain binding promotes auto-inhibition and homo-oligomerization or hetero-oligomerization. Recent studies have revealed that ERM proteins transduce growth signals, and have shed new light on how merlin links cell growth to the cytoskeleton.

摘要

ERM（埃兹蛋白、根蛋白和膜突蛋白）蛋白家族是将肌动蛋白微丝与质膜相连的连接蛋白。神经纤维瘤病2型（NF2）肿瘤抑制基因产物默林与ERM蛋白高度同源。在ERM蛋白和默林中，结构域间结合促进自身抑制以及同型寡聚化或异型寡聚化。最近的研究表明，ERM蛋白可转导生长信号，并为默林如何将细胞生长与细胞骨架联系起来提供了新的线索。