在猪乳腺内注射Gadomer-17后进行的T1加权磁共振淋巴造影。
T1-weighted MR-lymphography after intramammary administration of Gadomer-17 in pigs.
作者信息
Staatz G, Spüntrup E, Buecker A, Misselwitz B, Günther R W
机构信息
Dept. of Diagnostic Radiology, Aachen University of Technology, Berlin, Germany.
出版信息
Rofo. 2002 Jan;174(1):29-32. doi: 10.1055/s-2002-19551.
PURPOSE
To evaluate the enhancement of regional lymph nodes and lymphatic vessels after intramammary injection of Gadomer-17.
MATERIALS AND METHODS
T1-weighted MR-lymphography was performed in 8 domestic pigs after intramammary injection of 5 - 10 micromol/kg bodyweight (bw) Gadomer-17 on a 1.5 T-MR scanner. T1-weighted 3D gradient-echo images were acquired 10 to 120 minutes after contrast material injection in coronal and sagittal planes. The contrast enhancement of the draining lymphatic system was qualitatively assessed by two radiologists applying a three grade scale.
RESULTS
T1-Weighted MR-lymphography after intramammary injection of Gadomer-17 was feasible in each pig. A dose of 5 micromol/kg body weight Gadomer-17 was best suited for MR-lymphography of the mammary line and the draining lymphatic system. Enhancement of regional lymph nodes and lymphatic vessels was classified as good in 5, and excellent in three cases.
CONCLUSIONS
Intramammary injection of Gadomer-17 allows for good quality T1-weighted MR-lymphography of mammary gland draining regional lymph nodes and lymphatic vessels. This new technique might offer potential for the evaluation of the sentinel lymph node in patients with breast cancer.
目的
评估乳腺内注射Gadomer-17后区域淋巴结和淋巴管的强化情况。
材料与方法
对8头家猪在乳腺内注射5 - 10微摩尔/千克体重的Gadomer-17后，于1.5T磁共振扫描仪上进行T1加权磁共振淋巴造影。在注射对比剂后10至120分钟，在冠状面和矢状面采集T1加权三维梯度回波图像。由两名放射科医生采用三级评分法对引流淋巴系统的对比增强进行定性评估。
结果
每头猪在乳腺内注射Gadomer-17后进行T1加权磁共振淋巴造影均可行。5微摩尔/千克体重的Gadomer-17剂量最适合乳腺线和引流淋巴系统的磁共振淋巴造影。区域淋巴结和淋巴管的强化在5例中被分类为良好，3例为优秀。
结论
乳腺内注射Gadomer-17可实现对乳腺引流区域淋巴结和淋巴管的高质量T1加权磁共振淋巴造影。这项新技术可能为乳腺癌患者前哨淋巴结的评估提供潜力。
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