Hessman Y
Acta Chir Scand. 1975;141(5):393-8.
In association with trauma the storage of glycogen, especially in skeletal muscle, is reduced. An increased release of adrenalin may be one of the causes of this phenomenon. In this study the effect of exogenously supplied adrenalin (0.5 mug/kg/min) on the storage of glycogen in the liver and skeletal muscle during a standardized infusion of glucose was studied in rats. A significant reduction of the glycogen storage in the liver was recorded. In the muscle the glycogen storage was practically eliminated. Simultaneous determinations of the serum insulin concentration showed very low insulin levels on administration of adrenalin, indicating a blockade of the insulin release in the beta-cells. When insulin was given at the same time the glycogen storage was almost completely normalized. This suggests that the deficiency of circulating insulin occurring on administration of adrenalin may be responsible for the lack of glycogen storage in the muscle.
与创伤相关的是，糖原的储存，尤其是骨骼肌中的糖原储存会减少。肾上腺素释放增加可能是这一现象的原因之一。在本研究中，在大鼠中研究了在标准输注葡萄糖期间外源性给予肾上腺素（0.5微克/千克/分钟）对肝脏和骨骼肌中糖原储存的影响。记录到肝脏中糖原储存显著减少。在肌肉中，糖原储存几乎完全消失。同时测定血清胰岛素浓度显示，给予肾上腺素时胰岛素水平非常低，表明β细胞中胰岛素释放受阻。当同时给予胰岛素时，糖原储存几乎完全恢复正常。这表明给予肾上腺素时循环胰岛素的缺乏可能是肌肉中糖原储存不足的原因。
