Ding D, Deng Q, Zhang H
Department of Respiratory Medicine, Shanxian Central Hospital, Shanxian 274300, China.
Zhonghua Jie He He Hu Xi Za Zhi. 2001 Jan;24(1):32-4.
To investigate the effects of intrapleural urokinase in the prevention of pleural thickening and loculated pleural effusions by tuberculous pleural effusion.
Eighty-one patients with tuberculous pleural effusion were randomized into 2 groups, intrapleural urokinase group (group I) and conventional group (group C). The patients in group I were injected with urokinase 100 000 IU intrapleurally after each thoracocentesis on twice a week basis, other therapies were similar to group C.
The mean volume of fluid drained in group I was (3 981 +/- 573) ml, while it was (3 045 +/- 498) ml in group C (P < 0.01). The mean thickness of pleura in group I was (1.10 +/- 0.20) mm, but it was (1.40 +/- 0.30) mm in group C (P < 0.01), the incidence of pleural adhesion and location in group I was 10%, while it was 36% in group C (P < 0.01). The mean number of injection was (4.6 +/- 1.4) (ranged 3 approximately 8). The resolution time of pleural effusion was prolonged slightly, but there was no significant difference between two groups.
Intrapleural urokinase can evidently increase the volume of pleural effusion drained and prevent pleural thickening and adhesion.
探讨胸腔内注射尿激酶对结核性胸腔积液所致胸膜增厚及包裹性胸腔积液的预防作用。
81例结核性胸腔积液患者随机分为两组，即胸腔内注射尿激酶组（Ⅰ组）和常规治疗组（C组）。Ⅰ组患者每次胸腔穿刺抽液后胸腔内注射尿激酶10万IU，每周2次，其他治疗同C组。
Ⅰ组胸腔积液平均引流量为（3981±573）ml，C组为（3045±498）ml（P<0.01）。Ⅰ组胸膜平均厚度为（1.10±0.20）mm，C组为（1.40±0.30）mm（P<0.01）。Ⅰ组胸膜粘连及包裹发生率为10%，C组为36%（P<0.01）。平均注射次数为（4.6±1.4）次（范围3～8次）。胸腔积液消退时间稍有延长，但两组间无显著差异。
胸腔内注射尿激酶能明显增加胸腔积液引流量，预防胸膜增厚及粘连。
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