Pérez Sánchez Cristina, Casas-Tintó Sergio, Sánchez Lucas, Rey-Campos Javier, Granadino Begoña
Centro Investigaciones Biológicas CSIC, Velázquez 144, 28006, Madrid, Spain.
Mech Dev. 2002 Feb;111(1-2):163-6. doi: 10.1016/s0925-4773(01)00603-7.
DmFoxF is a novel Drosophila fork head domain factor, which is expressed in the visceral mesoderm of the embryo. Our data suggest that DmFoxF is the fly orthologue of the vertebrates FOXF1 and FOXF2 transcription factors. DmFoxF shares homology with FOXF1 and FOXF2 in its fork head domain, and it is able to specifically bind DNA sequences recognized by these vertebrate fork head factors. In stage 10-11 embryos, the DmFoxF protein is detected into the nuclei of cells of the presumptive visceral mesoderm. It localizes at the segmental cell clusters of the mesoderm, which will eventually develop to surround the midgut endoderm. DmFoxF is also expressed in the proctodeal mesoderm, which will develop into the visceral mesoderm of the hindgut.
DmFoxF是一种新型的果蝇叉头结构域因子,在胚胎的内脏中胚层表达。我们的数据表明,DmFoxF是脊椎动物FOXF1和FOXF2转录因子在果蝇中的同源物。DmFoxF在其叉头结构域与FOXF1和FOXF2具有同源性,并且能够特异性结合这些脊椎动物叉头因子识别的DNA序列。在10-11期胚胎中,可在假定的内脏中胚层细胞的细胞核中检测到DmFoxF蛋白。它定位于中胚层的节段性细胞簇,这些细胞簇最终将发育为围绕中肠内胚层。DmFoxF也在后肠原基中胚层表达,该中胚层将发育为后肠的内脏中胚层。