Calza L, Manfredi R, Chiodo F
Sezione di Malattie Infettive, Dipartimento di Medicina Clinica Specialistica e Sperimentale, Università Alma Mater, Policlinico S. Orsola, Bologna.
Recenti Prog Med. 2001 Dec;92(12):717-26.
Anthrax is a serious bacterial infection sustained by Bacillus anthracis and occurring in most mammals, especially grazing herbivors, but it can also involve humans when bacterial endospores enter the body through abrasions in the skin or by inhalation or ingestion. Human disease results from contact with infected animals or contaminated animal products, while there are no known cases of human-to-human transmission. The most common form of human anthrax is the cutaneous infection, usually curable with antimicrobial therapy and rarely leading to systemic and fatal disease; on the other hand, gastrointestinal and inhalatory forms (resulting from inhalation or ingestion of endospores) are very uncommon, but they show a mortality rate approaching 100 percent, usually related to septic and toxic shock. For centuries, anthrax has caused disease in animals and only a few cases in humans, with some outbreaks in developing countries. Today, after the new events in the United States, at least 17 nations are believed to have offensive biological weapon programs, and this old bacterial infection became a modern menace to world safety.
炭疽病是一种由炭疽杆菌引起的严重细菌感染,大多数哺乳动物都可能感染,尤其是食草动物,但当细菌芽孢通过皮肤擦伤、吸入或摄入进入人体时,也可能感染人类。人类疾病是由接触受感染动物或受污染的动物产品引起的,目前尚无已知的人传人病例。人类炭疽病最常见的形式是皮肤感染,通常用抗菌疗法即可治愈,很少导致全身性和致命疾病;另一方面,胃肠道和吸入性炭疽(由吸入或摄入芽孢引起)非常罕见,但死亡率接近100%,通常与败血症和中毒性休克有关。几个世纪以来,炭疽病一直在动物中引发疾病,在人类中仅有少数病例,在一些发展中国家曾有过疫情爆发。如今,在美国发生新事件之后,据信至少有17个国家拥有进攻性生物武器计划,这种古老的细菌感染成为了对世界安全的现代威胁。