Anticonvulsant activity of reaction products of 5,5-diphenylhydantoin with substituted methylene bromides.
作者信息
Usifoh C O
机构信息
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Nigeria.
出版信息
Arch Pharm (Weinheim). 2001 Nov;334(11):366-8. doi: 10.1002/1521-4184(200112)334:11<366::AID-ARDP366>3.0.CO;2-Q.
Abstract
Some derivatives of 5,5-diphenylhydantoin (phenytoin) were synthesized by the alkylation of phenytoin with substituted methylene bromides. The hydantoins were evaluated for possible anticonvulsant activity in the maximal electroshock (MES)- and subcutaneous pentylenetetrazole (ScMet)-induced seizures and for neurotoxicity in the rotorod test in mice and rats.
摘要
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