放射性核素肺灌注显像在先天性心脏病患者肺动脉高压评估中的应用
[Radionuclide pulmonary perfusion imaging in evaluating pulmonary hypertension in patients with congenital heart disease].
作者信息
Pan S, Xiao M, Liu Y, Hu S, Shi R, Liu X, Yu J, Li S, Tian Y
机构信息
Department of Cardiovascular Surgery, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences, Beijing 100037.
出版信息
Zhonghua Wai Ke Za Zhi. 1998 Mar;36(3):166-8.
OBJECTIVE
To evaluate the degree of pulmonary hypertension in patients with congenital heart disease (CHD) by using radionuclide pulmonary perfusion imaging.
METHOD
The pulmonary perfusion in 81 patients with left to right cardiac shunts was examined by scintigram with macroaggregates of (99m)Tc-labeled human serum albumin (PPS). PPS was analyzed for (1) lung regional radionuclide count (LRC), (2) right upper and lower lung count ratio (RULR), (3) kidney count ratio (KCR). The results were compared with those of cardiac catheterization exam.
RESULT
There were correlation between mean pulmonary arterial pressure (mPAP), total pulmonary resistance (TPR), and PPS (KCR, RULR with mPAP gamma = 0.25, 0.35; LRC, KCR with TPR gamma = -0.34, 0.29). Five patients repeated PPS test after early operation. There were no changes in PPS.
CONCLUSION
The degree of reversibility of pulmonary hypertension in patients with CHD could be quantitatively analysed by PPS.
目的
利用放射性核素肺灌注显像评估先天性心脏病（CHD）患者的肺动脉高压程度。
方法
采用（99m）Tc标记的人血清白蛋白大颗粒聚合体闪烁显像法（PPS）检测81例左向右分流型心脏病患者的肺灌注情况。分析PPS的（1）肺局部放射性核素计数（LRC）、（2）右上肺与右下肺计数比值（RULR）、（3）肾脏计数比值（KCR）。将结果与心导管检查结果进行比较。
结果
平均肺动脉压（mPAP）、总肺阻力（TPR）与PPS（KCR、RULR与mPAP的γ值分别为0.25、0.35；LRC、KCR与TPR的γ值分别为-0.34、0.29）之间存在相关性。5例患者在早期手术后重复进行PPS检查。PPS无变化。
结论
可通过PPS对CHD患者肺动脉高压的可逆程度进行定量分析。
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