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[硝鲁林——一种新型的俄罗斯原创亚硝基甲基脲类药物]

[Nitrullin -- a new original Russian drug of the nitrosomethylurea group].

作者信息

Gorbunova V A, Orel N F, Semina O V, Besova N S, Kadagidze Z G

机构信息

N.N. Blokhin Center for Oncology Research, Russian Academy of Medical Sciences, Moscow.

出版信息

Vopr Onkol. 2001;47(6):680-3.

Abstract

Hematologic thrombopenia and leukopenia formation limits use of nitrullin as a toxic hazard. The drug showed moderate effect in treating inoperable non-small cell cancer of the lung and satisfactory end results. The treatment had marked symptomatic effect in patients with this cancer and, as a consequence, improved the quality of life. Nutrullin had immuno-modulating effect. Its application alone or in combination with VPN showed good results in the management of small-cell cancer of the lung.

摘要

血液学血小板减少和白细胞减少的形成限制了硝鲁林作为一种有毒有害物质的使用。该药物在治疗无法手术的非小细胞肺癌方面显示出中等效果,且最终结果令人满意。该治疗方法对患有这种癌症的患者有显著的症状改善效果,从而提高了生活质量。硝鲁林具有免疫调节作用。其单独应用或与VPN联合应用在小细胞肺癌的治疗中显示出良好效果。

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