Solans R, Bosch J A, Selva A, Orriols R, Vilardell M
Department of Internal Medicine, Vall d'Hebrón University General Hospital, Barcelona 08035, Spain.
Thorax. 2002 Feb;57(2):183-5. doi: 10.1136/thorax.57.2.183.
Several cases of eosinophilic conditions including Churg-Strauss syndrome (CSS) have recently been reported in asthmatic patients being treated with antileukotriene receptor antagonists. One patient with CSS who experienced a clinical relapse after treatment with montelukast and two asthmatic patients who developed CSS while receiving montelukast treatment are described. In one case reduction in the dose of oral steroid preceded the onset of CSS. To our knowledge, no case of CSS relapse has previously been reported in association with leukotriene antagonists.
近期有报道称,在使用抗白三烯受体拮抗剂治疗的哮喘患者中出现了几例嗜酸性粒细胞相关病症,包括变应性肉芽肿性血管炎(CSS)。本文描述了1例在使用孟鲁司特治疗后出现临床复发的CSS患者,以及2例在接受孟鲁司特治疗期间发生CSS的哮喘患者。其中1例在CSS发作前口服类固醇剂量有所减少。据我们所知,此前尚无与白三烯拮抗剂相关的CSS复发病例报道。