Zhao G, Li Y, Shao M, Ding Y
Beijing Institute of Functional Neurosurgery, Beijing Xuanwu Hospital, Beijing 100053.
Zhonghua Wai Ke Za Zhi. 1999 Aug;37(8):482-4.
To evaluate the outcome of microelectrode-guided posteroventral pallidotomy (PVP) for L-dopa induced dyskinesia in patients with Parkinson's disease.
Thirty-six patients with dyskinesia were evaluated with unified Parkinson's disease rating scale (UPDRS) before and after operation. Duration and disability of dyskinesia were analyzed respectively.
The total surgical improvement for dyskinesia was 76.2%. Duration improvement was 88.8% and disability 79.7%. Significant change (P < 0.05) happened postoperatively. Seventeen patients were followed up for 3 months. The result showed a stable improvement for dyskinesia.
L-dopa induced dyskinesia may disappear or be improved after PVP. Surgical treatment promises a maximum L-dopa therapy without any severe pharmaceutical complications. Synergic treatment of drug and surgery are a new strategy for Parkinson's disease.
评估微电极引导下的帕金森病患者后腹侧苍白球切开术（PVP）治疗左旋多巴诱导的异动症的疗效。
36例异动症患者在手术前后采用统一帕金森病评定量表（UPDRS）进行评估。分别分析异动症的持续时间和残疾情况。
异动症的总体手术改善率为76.2%。持续时间改善率为88.8%，残疾改善率为79.7%。术后发生显著变化（P<0.05）。17例患者随访3个月。结果显示异动症改善稳定。
PVP术后左旋多巴诱导的异动症可能消失或改善。手术治疗有望实现最大程度的左旋多巴治疗且无任何严重药物并发症。药物与手术协同治疗是帕金森病的一种新策略。
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