[肉碱对大鼠全肠外营养所致肝脂肪变性的治疗作用研究]
[Study on therapeutic effect of carnitine on hepatic steatosis caused by total parenteral nutrition in rats].
作者信息
Liang L, Luo S, Zheng J, Huang J
机构信息
Department of Hepatobiliary, First Affiliated Hospital of Sun Yat-sen University of Medical Sciences, Guangzhou 510080.
出版信息
Zhonghua Wai Ke Za Zhi. 1999 Aug;37(8):500-2, 33.
OBJECTIVE
To study the hepatic steatosis-minimizing effects of carnitine supplemented total parenteral nutrition (TPN).
METHODS
Eighteen normal Wistar rats and nineteen cirrhotic Wistar rats were randomly divided into three groups, respectively: group A (12), chow and libitum; group B (13), TPN for one week group C (12), TPN with carnitine. Liver functions were tested at the seventh day, and also, the liver was resected for histological studies and lipid content determination.
RESULTS
Hepatic lipid content was significantly elevated and hepatic steatosis was noted in group B. Hepatic lipid content and hepatic lipid deposit were significantly lowered when carnitine was added to the TPN solution.
CONCLUSIONS
Carnitine can minimize hepatic steatosis caused by TPN.
目的
研究补充肉碱的全胃肠外营养（TPN）对肝脏脂肪变性的最小化作用。
方法
将18只正常Wistar大鼠和19只肝硬化Wistar大鼠分别随机分为三组：A组（12只），自由摄食普通饲料；B组（13只），接受一周的TPN；C组（12只），接受添加肉碱的TPN。在第7天检测肝功能，同时切除肝脏进行组织学研究和脂质含量测定。
结果
B组肝脏脂质含量显著升高，出现肝脏脂肪变性。当在TPN溶液中添加肉碱时，肝脏脂质含量和肝脏脂质沉积显著降低。
结论
肉碱可使TPN引起的肝脏脂肪变性最小化。
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