2-氯脱氧腺苷治疗毛细胞白血病
2-CdA in the treatment of hairy cell leukaemia.
作者信息
Abhyankar D, Bajpai S, Saikia T, Gopal R, Nair C N, Advani S H
机构信息
Department of Medical Oncology, Tata Memorial Hospital, Mumbai.
出版信息
J Assoc Physicians India. 2001 Aug;49:785-7.
INTRODUCTION
Hairy cell leukaemia (HCL) is a rare lymphoproliferative disorder. Treatment options available are splenectomy, interferon, DCF and 2-CdA. 2-CdA is considered to have curative potential as proved by the other studies.
METHODS
We gave 2-CdA in a dose of 0.09/kg/day as a continuous infusion in sixteen patients of hairy cell leukaemia.
RESULTS
Three patients developed neutropenia post transfusion. At the end of three months all patients were in remission. Two patients relapsed at the median follow-up of 15 months.
CONCLUSION
2-CdA in HCL can achieve complete remission, prolonged survival and care as well.
引言
毛细胞白血病（HCL）是一种罕见的淋巴细胞增殖性疾病。现有的治疗选择包括脾切除术、干扰素、DCF和2-氯脱氧腺苷（2-CdA）。其他研究证明，2-CdA被认为具有治愈潜力。
方法
我们对16例毛细胞白血病患者以0.09/kg/天的剂量持续输注2-CdA。
结果
3例患者输血后出现中性粒细胞减少。3个月末所有患者均缓解。2例患者在中位随访15个月时复发。
结论
2-CdA治疗毛细胞白血病可实现完全缓解、延长生存期并提供良好护理。
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