苯乙双胍对大鼠回肠胆汁酸和水分吸收的体内抑制作用。

Inhibition of bile acid and water absorption by phenethylbiguanide in rat ileum in vivo.

作者信息

Caspary W F, Lücke H

出版信息

Digestion. 1975;12(3):179-82. doi: 10.1159/000197672.

DOI:10.1159/000197672

Abstract

Since biguanides are known to inhibit hexose and amino acid absorption in vivo and in vitro as well as vitamin B12 absorption the effect of phenethylbiguanide on taurocholate (TC) and water absorption was measured in rat ileum in vivo. Phenethylbiguanide exhibited a time-dependent inhibitory effect on TC- and water absorption. If the bile acid inhibitory effect of biguanides can be found in diabetics on treatment with biguanides it might explain the observed cholesterol-lowering effect of these oral antidiabetic drugs.

摘要

由于已知双胍类药物在体内和体外均能抑制己糖和氨基酸的吸收以及维生素B12的吸收，因此在大鼠体内回肠中测定了苯乙双胍对牛磺胆酸盐（TC）和水吸收的影响。苯乙双胍对TC和水的吸收表现出时间依赖性抑制作用。如果在接受双胍类药物治疗的糖尿病患者中能发现双胍类药物对胆汁酸的抑制作用，那么这可能解释了这些口服降糖药所观察到的降胆固醇作用。