Morita R, Nakamura S, Kaneko K, Suga M, Kyo S
Department of Cardiovascular and Thoracic Surgery, Saitama Medical School, Saitama, Japan.
Kyobu Geka. 2002 Feb;55(2):181-3.
A 45-year-old female with solitary fibrous tumor (SFT) of the pleura was reported. Chest X-ray and CT scan on admission showed a large tumor in the right thoracic cavity. A preoperative needle biopsy was performed. The microscopic appearance of biopsied specimen revealed many spindle cells. And an immunohistochemical study was positive for CD 34 and negative for keratin, epithelial membrane antigen, alpha-smooth muscle actin, S-100 protein. So SFT was strongly suspected and an operation was performed. A tumor arised from the visceral pleura of right middle lobe and was pedunculated. The tumor was 13 x 10 x 7.5 cm in size. An immunohistochemical study of the tumor was positive for CD 34, and negative for SMA, ki-67. From these immunohistochemical stainings and microscopic findings, the tumor was diagnosed as SFT. An immunohistochemical study of the tumor seems to be very useful for the diagnosis of SFT.
报道了一名45岁患有胸膜孤立性纤维瘤(SFT)的女性。入院时胸部X线和CT扫描显示右胸腔有一个大肿瘤。进行了术前针吸活检。活检标本的显微镜下表现显示有许多梭形细胞。免疫组化研究显示CD 34阳性,角蛋白、上皮膜抗原、α-平滑肌肌动蛋白、S-100蛋白阴性。因此强烈怀疑为SFT并进行了手术。肿瘤起源于右中叶脏层胸膜,有蒂。肿瘤大小为13×10×7.5 cm。肿瘤的免疫组化研究显示CD 34阳性,SMA、ki-67阴性。根据这些免疫组化染色和显微镜检查结果,该肿瘤被诊断为SFT。肿瘤的免疫组化研究似乎对SFT的诊断非常有用。