[On mechanisms underlying bronchial obstruction in chronic dust bronchitis in workers of deep coal mines].

Healthy miners demonstrated increased relative levels of lysophosphatidyl choline and especially phosphatidyl inositol subunits. Metabolism of the latter could result in membrane accumulation of inositol triphosphate leading to cytoplasmic calcium increase and to bronchial smooth muscles contraction. Oral 20% choline chloride solution lowers bronchospasm in dust bronchitis patients with decreased serum subunits of phosphatidyl inositol and increased serum levels of phosphatidyl choline.