Naryzhnaia N V, Krylatov A V, Maslov L N, Lishmanov Iu B, Gross G J, Stephano J B
Research Institute of Cardiology, Russian Acad. Med. Sci., 634050, Tomsk, 111a Kievsjaya St., Russia.
Ross Fiziol Zh Im I M Sechenova. 2001 Dec;87(12):1617-25.
It has been found that stimulation of delta-1 opioid receptors by intravenous administration of DPDPE (0.5 mg/kg) decreases the incidence of ischemic and reperfusion-induced arrhythmias and also increases myocardial tolerance to the arrhythmogenic action of epinephrine in rats. Pretreatment with a selective delta-2 agonist, DSLET, had no antiarrhythmic effect. The inhibition of the enzymatic breakdown of endogenous enkephalins by intravenous administration of acetorphan decreased the incidence of epinephrine-induced arrhythmias. Pretreatment with a selective delta opioid receptor antagonist, ICI-174.868, completely abolished this antiarrhythmic effect. Adaptation of rats to repeated immobilization stress during 12 days increased myocardial tolerance to the arrhythmogenic action of coronary artery occlusion (10 min) and reperfusion (10 min). Pretreatment with a selective delta opioid receptor antagonist, TIPP(Psy), did not abolish the antiarrhythmic effect of adaptation to immobilization stress. It seems that endogenous agonists of delta opioid receptors are not involved in the antiarrhythmic effect resulting from adaptation to stress.
已发现静脉注射DPDPE（0.5毫克/千克）刺激δ-1阿片受体可降低缺血和再灌注诱导的心律失常发生率，还可提高大鼠心肌对肾上腺素致心律失常作用的耐受性。用选择性δ-2激动剂DSLET预处理无抗心律失常作用。静脉注射阿醋托芬抑制内源性脑啡肽的酶促降解可降低肾上腺素诱导的心律失常发生率。用选择性δ阿片受体拮抗剂ICI-174.868预处理可完全消除这种抗心律失常作用。大鼠在12天内反复适应固定应激可提高心肌对冠状动脉闭塞（10分钟）和再灌注（10分钟）致心律失常作用的耐受性。用选择性δ阿片受体拮抗剂TIPP(Psy)预处理并未消除适应固定应激的抗心律失常作用。似乎δ阿片受体的内源性激动剂不参与应激适应产生的抗心律失常作用。
