Weismüller Peter, Kuly Simone, Brandts Bodo, Kattenbeck Klaus, Ranke Carsten, Trappe Hans J
Department of Cardiology and Angiology, University Hospital Herne, Ruhr-University Bochum, Herne, Germany.
J Am Coll Cardiol. 2002 Feb 20;39(4):689-94. doi: 10.1016/s0735-1097(01)01798-3.
The purpose of this study was to answer the question of whether stimulation after administration of catecholamines is mandatory for identifying unsuccessful ablations of atrioventricular node re-entrant tachycardia (AVNRT).
The success of radiofrequency (RF) catheter ablation in AVNRT is confirmed in many centers by noninducibility of tachycardias during stimulation after the administration of catecholamines.
A total of 131 patients (81 women and 50 men; mean age 53.6 +/- 13.7 years [range 20 to 77]) were studied. Electrical stimulation was performed without and with the beta-adrenergic amine Orciprenaline (metaproterenol) before and after RF catheter ablation.
In 100 patients (76.3%; confidence interval [CI] 68.1% to 83.3%) an AVNRT was inducible without administration of Orciprenaline. Thirty minutes after the initially successful ablation in 95 patients, tachycardia was inducible in none of these patients, not even after Orciprenaline administration. In the 31 patients (23.7%; CI 16.7% to 31.9%) in whom there was no tachycardia inducible before ablation, Orciprenaline was given, and the stimulation protocol was repeated. In only five patients (3.8%; CI 1.3% to 8.7%) was there still no tachycardia inducible. After an initially successful ablation in the 26 patients who had inducible tachycardias with Orciprenaline before ablation, no tachycardia could be re-induced. After Orciprenaline, the tachycardia was inducible again in only one patient.
Only patients who require catecholamines for tachycardia induction before ablation need catecholamines for control of the success of the ablation of AVNRT.
本研究旨在回答对于房室结折返性心动过速(AVNRT)消融失败的识别,在给予儿茶酚胺后进行刺激是否必不可少这一问题。
在许多中心,射频(RF)导管消融治疗AVNRT的成功是通过给予儿茶酚胺后刺激期间心动过速不能被诱发来证实的。
共研究了131例患者(81例女性和50例男性;平均年龄53.6±13.7岁[范围20至77岁])。在RF导管消融前后,分别在未使用和使用β-肾上腺素能胺奥西那林(间羟异丙肾上腺素)的情况下进行电刺激。
100例患者(76.3%;置信区间[CI]68.1%至83.3%)在未给予奥西那林的情况下可诱发AVNRT。在95例最初成功消融的患者中,30分钟后,这些患者中无一例能诱发心动过速,即使在给予奥西那林后也不能。在31例(23.7%;CI 16.7%至31.9%)消融前不能诱发心动过速的患者中,给予了奥西那林,并重复了刺激方案。只有5例患者(3.8%;CI 1.3%至8.7%)仍不能诱发心动过速。在26例消融前使用奥西那林可诱发心动过速的患者中,最初成功消融后,未再诱发心动过速。给予奥西那林后,只有1例患者再次诱发了心动过速。
只有在消融前需要儿茶酚胺来诱发心动过速的患者,才需要儿茶酚胺来控制AVNRT消融的成功与否。