平衡不稳定性：端粒酶和端粒功能障碍在肿瘤发生中的双重作用

Balancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesis.

作者信息

Hackett Jennifer A, Greider Carol W

机构信息

Predoctoral Training Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, MD 21205, USA.

出版信息

Oncogene. 2002 Jan 21;21(4):619-26. doi: 10.1038/sj.onc.1205061.

DOI:10.1038/sj.onc.1205061

PMID:11850787

Abstract

Telomere shortening and telomerase activation both occur in human tumors. Telomere shortening has been proposed to have two conflicting roles in tumorigenesis: tumor suppression and initiation of chromosomal instability. Similarly, while telomerase activation is suggested to be necessary for tumor growth, telomerase may help to stabilize genomic instability. Here we review what is known about these conflicting roles and propose a framework to understand the role of telomerase in cancer progression.

摘要

端粒缩短和端粒酶激活在人类肿瘤中均会发生。有人提出端粒缩短在肿瘤发生过程中具有两种相互矛盾的作用：肿瘤抑制和引发染色体不稳定。同样，虽然有人认为端粒酶激活对肿瘤生长是必要的，但端粒酶可能有助于稳定基因组不稳定。在此，我们综述关于这些相互矛盾作用的已知情况，并提出一个框架来理解端粒酶在癌症进展中的作用。