氧钒（IV）配合物对非糖尿病和链脲佐菌素诱导的糖尿病大鼠的影响。
Effect of oxovanadium(IV) complexes on nondiabetic and streptozotocin-diabetic rats.
作者信息
Krosniak M, Zachwieja Z, Filipek B, Zygmunt M, Grybos R
机构信息
Department of Food Chemistry and Nutrition, School of Medicine, Jagiellonian University, Medyczna 9, Kraków 30-688, Poland.
出版信息
Arch Pharm (Weinheim). 2001 Dec;334(12):388-92. doi: 10.1002/1521-4184(200112)334:12<388::AID-ARDP388>3.0.CO;2-9.
The effects of vanadium complexes with organic ligands, [VO(phen)2]SO4.3H2O, [VO(bpy)2]SO4.2H2O, and [VOCl2(Hmcp)2H2O], on blood glucose and plasma lipid levels were studied in nondiabetic and streptozotocin-diabetic rats and compared to that of [VO(mal)2] (the reference compound). The present results provide evidence that the compounds examined possess lower toxicity than [VO(mal)2]. One of the compounds examined, viz. [VO(bpy)2]SO4.2H2O, decreases, statistically significantly, the glucose level and a second one, viz. [VOCl2(Hmcp)2H2O], decreases, also significantly, the total cholesterol level.
研究了有机配体钒配合物[VO(phen)₂]SO₄·3H₂O、[VO(bpy)₂]SO₄·2H₂O和[VOCl₂(Hmcp)₂H₂O]对非糖尿病和链脲佐菌素诱导糖尿病大鼠血糖和血脂水平的影响，并与[VO(mal)₂]（参考化合物）进行比较。目前的结果表明，所检测的化合物毒性低于[VO(mal)₂]。所检测的化合物之一，即[VO(bpy)₂]SO₄·2H₂O，能显著降低血糖水平，另一种化合物[VOCl₂(Hmcp)₂H₂O]也能显著降低总胆固醇水平。
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