没有梦想，就没有痛苦。关闭脊髓闸门。
No DREAM, No pain. Closing the spinal gate.
作者信息
Costigan Michael, Woolf Clifford J
机构信息
Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Massachusetts General Hospital-East, Charlestown, MA 02129, USA.
出版信息
Cell. 2002 Feb 8;108(3):297-300. doi: 10.1016/s0092-8674(02)00640-2.
Pain transmission in the spinal cord is regulated by a balance of facilitatory and inhibitory influences operating on the neural circuits of the somatosensory system. The transcriptional repressor DREAM acts constitutively to suppress prodynorphin expression in spinal cord neurons. Knocking out DREAM results in sufficient dynorphin expression to produce a strong reduction in generalized pain behavior, highlighting the role that intracellular molecules play in modulating pain gating in the spinal cord.
脊髓中的疼痛传递是由作用于体感系统神经回路的促进性和抑制性影响之间的平衡来调节的。转录抑制因子DREAM持续发挥作用，抑制脊髓神经元中前强啡肽原的表达。敲除DREAM会导致强啡肽充分表达，从而使全身性疼痛行为大幅减少，这突出了细胞内分子在调节脊髓疼痛闸门中的作用。
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