Suhardja A, Kovacs K, Rutka J
Division of Neurosurgery, St. Michael's Hospital, Toronto, Ontario, Canada.
J Neurooncol. 2001 Dec;55(3):185-93. doi: 10.1023/a:1013819827162.
The diversity inherent in every organ has its roots in gene-expression variation and is revealed through distinctions in the molecular profile and hence the identity of individual cell type. Study into the molecular mechanisms of the development of individual cell type within the pituitary, which is under the control of transcription factors, has provided a basis for a deeper insight into the molecular mechanisms underlying the pathogenesis of a variety of hormone-producing pituitary tumors. Identification of some of these transcription factors in pituitary adenomas further supports their role in the pathogenesis of pituitary adenomas. Understanding the molecular mechanisms of regulation of proliferation of pituitary cell types by transcription factors offers a basis for hope that rational genetic or pharmacologic therapies for pituitary tumors can be designed in the future.
每个器官固有的多样性源于基因表达变异，并通过分子特征的差异以及由此产生的个体细胞类型的特性得以展现。对垂体中在转录因子控制下的个体细胞类型发育的分子机制进行研究，为更深入了解各种产生激素的垂体肿瘤发病机制背后的分子机制提供了基础。在垂体腺瘤中鉴定出其中一些转录因子，进一步支持了它们在垂体腺瘤发病机制中的作用。了解转录因子对垂体细胞类型增殖的调控分子机制，为未来能够设计出针对垂体肿瘤的合理基因或药物疗法带来了希望。
