Efficient human immunodeficiency virus replication requires a fine-tuned level of transcription.
作者信息
Marzio Giuseppe, Vink Monique, Verhoef Koen, de Ronde Anthony, Berkhout Ben
机构信息
Department of Human Retrovirology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
出版信息
J Virol. 2002 Mar;76(6):3084-8. doi: 10.1128/jvi.76.6.3084-3088.2002.
Abstract
Transcription represents a crucial step in the life cycle of human immunodeficiency virus (HIV) and is highly regulated. Here we show that the strength of the viral long terminal repeat (LTR) promoter is optimized for efficient replication. Artificially increasing the rate of LTR-driven transcription was strongly detrimental for viral fitness, and HIV was able to regain replication capacity by selecting for variants with a weaker LTR. Strikingly, the strength of the evolved promoter was equivalent to that of the wild-type LTR.
摘要
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