[Effect of plant melanin pigment on the clastogenic effects of chemical mutagens in mice].
作者信息
Alekseeva T N, Durnev A D, Kulakova A V, Oreshchenko A V, Samusenok L V, Ogarkov B N, Seredenin S B
机构信息
Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
出版信息
Eksp Klin Farmakol. 2001 Nov-Dec;64(6):56-9.
PMID:11871241
Abstract
The chromosome aberration assay in the bone marrow cells of C57BL/6 mice showed that melanin pigment (MP) in a dose range from 0.01 to 10 mg/kg does not influence the clastogenic effect of dioxidine (200 mg/kg, i.p.), while reducing the clastogenic effect of cyclophosphamide (20 mg/kg, i.p.) by a factor of 1.5-4 in various treatment regimes depending on the mutagen injection time.
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