[双表型急性白血病的临床特征研究]

[Study on the clinical characteristics of biphenotypic acute leukemia].

作者信息

Mi Y, Bian S, Meng Q, Xue Y, Yu M, Chen G, Li D, Chen Y, Qian L

机构信息

Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union of Medical College, Tianjin 300020, China.

出版信息

Zhonghua Xue Ye Xue Za Zhi. 2000 Jul;21(7):352-4.

PMID:11877003

Abstract

OBJECTIVE

To analyze the biological characteristics and the treatment outcome of adult biphenotypic acute leukemia.

METHODS

Immunophenotypes were examined using indirect immunofluorescence method. Biphenotypic acute leukemia (BAL) was diagnosed according to EGIL scoring system.

RESULTS

(1) The incidence of BAL in acute leukemia was 3.4%. Percentage for coexpression of B lymphoid and myeloid antigens was 68.4%, for T lymphoid and myeloid antigens 21.1%, for B, T lymphoid and myeloid antigens 10.5%. (2) CD(34) was expressed in 43.75% of the BAL cases. (3) Cytogenetic analysis revealed normal and abnormal karyotypes in 41.7% and 58.3% of the BAL cases, respectively. (4) Six of 19 patients achieved completed remission (CR), but the disease free survivals were all less than 6 months. Treatment outcomes were negatively related to the expression of CD(34) antigen and cytogenetic findings. The BAL patients were poorly responded to therapeutic regimens directed to AML.

CONCLUSION

Coexpression of B/M antigens is the commonest subtype in BAL. BAL had a poor prognosis, especially treated with induction regimen directed to AML.

摘要

目的

分析成人双表型急性白血病的生物学特征及治疗结果。

方法

采用间接免疫荧光法检测免疫表型。根据EGIL评分系统诊断双表型急性白血病（BAL）。

结果

（1）急性白血病中BAL的发病率为3.4%。B淋巴细胞和髓系抗原共表达的比例为68.4%，T淋巴细胞和髓系抗原共表达的比例为21.1%，B、T淋巴细胞和髓系抗原共表达的比例为10.5%。（2）43.75%的BAL病例表达CD(34)。（3）细胞遗传学分析显示，BAL病例中核型正常和异常的分别占41.7%和58.3%。（4）19例患者中有6例达到完全缓解（CR），但无病生存期均小于6个月。治疗结果与CD(34)抗原表达及细胞遗传学结果呈负相关。BAL患者对针对急性髓系白血病（AML）的治疗方案反应不佳。