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Structured treatment interruptions in HIV/AIDS therapy.

作者信息

Lisziewicz Julianna, Lori Franco

机构信息

Research Institute for Genetic and Human Therapy, IRCCS Policlinico S. Matteo, P. le Golgi, 2 - 27100, Pavia, Italy.

出版信息

Microbes Infect. 2002 Feb;4(2):207-14. doi: 10.1016/s1286-4579(01)01529-5.

DOI:10.1016/s1286-4579(01)01529-5
PMID:11880054
Abstract

Structured treatment interruption (STI) has been investigated for three distinct clinical scenarios: during acute infection with the goal of immune reconstitution and auto immunization; during chronic infection, to decrease the amount and toxicity of antiretroviral drugs; and during virologic failure to restore response to subsequent antiretroviral therapy. The potential costs and benefits of STI should be determined.

摘要

相似文献

[1]
Structured treatment interruptions in HIV/AIDS therapy.

Microbes Infect. 2002-2

[2]
Structured treatment interruptions for the management of HIV infection.

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[3]
Biphasic decline of CD4 cell count during scheduled treatment interruptions.

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[4]
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[5]
Development of HIV with drug resistance after CD4 cell count-guided structured treatment interruptions in patients treated with highly active antiretroviral therapy after dual-nucleoside analogue treatment.

Clin Infect Dis. 2005-3-1

[6]
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AIDS. 2007-5-11

[7]
[Structured therapeutic interruption in patients infected with HIV-1 experiencing a block in their antiretroviral treatment: preliminary results].

Pathol Biol (Paris). 2001-9

[8]
Structured interruptions of highly active antiretroviral therapy in cycles of 4 weeks off/12 weeks on therapy in children having a chronically undetectable viral load cause progressively smaller viral rebounds.

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[9]
The concept of structured treatment interruptions in the management of patients with human immunodeficiency virus (HIV) disease: where are we currently?

HIV Clin Trials. 2003

[10]
[The current status of structured treatment interruption].

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引用本文的文献

[1]
In Silico Modeling in Infectious Disease.

Drug Discov Today Dis Models. 2007-10-1

[2]
Cellular reservoirs of HIV-1 and their role in viral persistence.

Curr HIV Res. 2008-9

[3]
Customizing treatment to the patient: adaptive treatment strategies.

Drug Alcohol Depend. 2007-5

[4]
Structured treatment interruptions (STI) in chronic unsuppressed HIV infection in adults.

Cochrane Database Syst Rev. 2006-7-19

[5]
Immunological and virological consequences of patient-directed antiretroviral therapy interruption during chronic HIV-1 infection.

Clin Exp Immunol. 2005-11

[6]
Boosting immunity by antiviral drug therapy: a simple relationship among timing, efficacy, and success.

Proc Natl Acad Sci U S A. 2003-2-18

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