暴发性肝衰竭患者神经肽（降钙素基因相关肽、血管活性肠肽、神经肽Y）的循环水平。

Circulating levels of neuropeptides (CGRP, VIP, NPY) in patients with fulminant hepatic failure.

作者信息

Strauss G I, Edvinsson L, Larsen F S, Møller K, Knudsen G M

机构信息

Department of Hepatology, Rigshospitalet, University of Copenhagen, Denmark.

出版信息

Neuropeptides. 2001 Jun-Aug;35(3-4):174-80. doi: 10.1054/npep.2001.0861.

DOI:10.1054/npep.2001.0861

PMID:11884208

Abstract

The present study investigated the circulating levels and cerebral fluxes of calcitonin gene-related peptide (CGRP), vasoactive intestinal peptide (VIP), and neuropeptide Y (NPY) and their relation to cerebral blood flow (CBF) during normoventilation and hyperventilation in patients with fulminant hepatic failure (FHF). Sixteen patients with FHF were studied and compared to six patients with cirrhosis of the liver. CBF was measured by the (133)Xe wash-out technique. Blood samples were obtained simultaneously from the artery and internal jugular bulb. Concentrations of CGRP and VIP were higher in FHF than in cirrhosis, 87 (55-218) vs. 29 (21-42) pmol/L, and 11 (6-29) vs. 5 (3-9)pmol/L, respectively. NPY was normal, none of the measures were related to CBF, and there was no detectable net brain fluxes. Hyperventilation did not alter any of the measures. CGRP and VIP in FHF seem to reflect hemodynamic changes in the systemic rather than in the cerebral circulation.

摘要

本研究调查了暴发性肝衰竭（FHF）患者在正常通气和过度通气期间降钙素基因相关肽（CGRP）、血管活性肠肽（VIP）和神经肽Y（NPY）的循环水平及脑通量，以及它们与脑血流量（CBF）的关系。对16例FHF患者进行了研究，并与6例肝硬化患者进行了比较。采用（133）Xe洗脱技术测量CBF。同时从动脉和颈内静脉球部采集血样。FHF患者中CGRP和VIP的浓度高于肝硬化患者，分别为87（55 - 218）pmol/L对29（21 - 42）pmol/L，以及11（6 - 29）pmol/L对5（3 - 9）pmol/L。NPY水平正常，各项指标均与CBF无关，且未检测到净脑通量。过度通气未改变任何指标。FHF患者中的CGRP和VIP似乎反映的是体循环而非脑循环中的血流动力学变化。