精神分裂症患者的年龄与局部脑血流量：前扣带回、额叶和顶叶皮质的年龄效应
Age and regional cerebral blood flow in schizophrenia: age effects in anterior cingulate, frontal, and parietal cortex.
作者信息
Schultz Susan K, O'Leary Daniel S, Boles Ponto Laura L, Arndt Stephan, Magnotta Vincent, Watkins G Leonard, Hichwa Richard D, Andreasen Nancy C
机构信息
Department of Radiology, University of Iowa College of Medicine, Iowa City, Iowa 52242-1000, USA.
出版信息
J Neuropsychiatry Clin Neurosci. 2002 Winter;14(1):19-24. doi: 10.1176/jnp.14.1.19.
Positron emission tomography ([(15)O] water PET) was used to examine the relationship between age and regional cerebral blood flow (rCBF) in schizophrenia. Forty-nine unmedicated male patients, ages 20-51, underwent imaging during an eyes-closed resting condition. Negative correlations were observed between age and rCBF in the anterior cingulate, as well as in frontal (Brodmann area 8) and parietal cortex (area 40) bilaterally. The observation of reduced rCBF in the anterior cingulate with increased age is consistent with previous findings in healthy subjects. In contrast, the reduced flow observed in the frontal and parietal regions may be unique to schizophrenia.
正电子发射断层扫描（[(15)O]水PET）用于研究精神分裂症患者年龄与局部脑血流量（rCBF）之间的关系。49名年龄在20至51岁之间的未接受药物治疗的男性患者在闭眼静息状态下接受了成像检查。在双侧前扣带回以及额叶（布罗德曼8区）和顶叶皮质（40区）中，观察到年龄与rCBF呈负相关。随着年龄增长前扣带回rCBF降低的观察结果与先前在健康受试者中的发现一致。相比之下，额叶和顶叶区域观察到的血流量减少可能是精神分裂症所特有的。
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