抑制猕猴晶状体中的碳酸酐酶不会诱发近视。

Inhibition of carbonic anhydrase in the lens does not induce myopia in cynomolgus monkeys.

作者信息

Wistrand P J

机构信息

Department of Ophthalmology, Akademiska Sjukhuset, University of Uppsala, Sweden.

出版信息

Ups J Med Sci. 2001;106(2):117-21. doi: 10.3109/2000-1967-164.

DOI:10.3109/2000-1967-164

PMID:11888067

Abstract

Refraction was measured in eyes of cynomolgus (Macaca irus) monkeys, before and during continuous intravenous infusion of large doses of the carbonic anhydrase (CA) inhibitors acetazolamide and ethoxzolamide. No changes of refraction were seen. Therefore, inhibition of CA in lens, cornea and retina does not appear to be the cause of the transient myopia and associated symptoms, occasionally observed in patients treated with CA inhibitors.

摘要

在恒河猴（食蟹猴）眼中测量了屈光，测量时间分别为连续静脉输注大剂量碳酸酐酶（CA）抑制剂乙酰唑胺和乙氧唑胺之前和期间。未观察到屈光变化。因此，晶状体、角膜和视网膜中CA的抑制似乎不是在用CA抑制剂治疗的患者中偶尔观察到的短暂性近视及相关症状的原因。