Di Matteo Vincenzo, Cacchio Marisa, Di Giulio Camillo, Esposito Ennio
Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro, Chieti, Italy.
Pharmacol Biochem Behav. 2002 Apr;71(4):727-34. doi: 10.1016/s0091-3057(01)00705-5.
There is substantial evidence that the functional status of mesocorticolimbic dopaminergic (DA) system originating in the ventral tegmental area (VTA) is under a phasic and tonic inhibitory control by the serotonergic system, which acts by stimulating serotonin(2C) (5-HT(2C)) receptor subtypes. This assertion is based upon a number of electrophysiological and biochemical data showing that 5-HT(2C) receptor agonists decrease, while 5-HT(2C) receptor antagonists enhance mesocorticolimbic DA function. On the other hand, it does not seem that 5-HT(2C) receptors play a relevant role in the control of nigrostriatal DA system originating in the substantia nigra pars compacta (SNc). The authors of this article review the most relevant data regarding the role of 5-HT(2C) receptors in the control of brain DA function and underline the importance of this subject in the search of new therapies for neuropsychiatric disorders such as depression, schizophrenia, drug addiction, and Parkinson's disease.
有大量证据表明，起源于腹侧被盖区（VTA）的中脑皮质边缘多巴胺能（DA）系统的功能状态受到血清素能系统的阶段性和紧张性抑制控制，该系统通过刺激血清素（2C）（5-HT（2C））受体亚型发挥作用。这一论断基于大量电生理和生化数据，这些数据表明5-HT（2C）受体激动剂会降低中脑皮质边缘DA功能，而5-HT（2C）受体拮抗剂则会增强该功能。另一方面，5-HT（2C）受体似乎在控制起源于黑质致密部（SNc）的黑质纹状体DA系统中并不发挥相关作用。本文作者回顾了有关5-HT（2C）受体在控制脑DA功能中作用的最相关数据，并强调了该主题在寻找治疗抑郁症、精神分裂症、药物成瘾和帕金森病等神经精神疾病新疗法方面的重要性。
