Herencia Felipe, López-García M Pilar, Ubeda Amalia, Ferrándiz M Luisa
Department of Pharmacology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andres Estelles s/n, 46100 Burjassot, Spain.
Nitric Oxide. 2002 Mar;6(2):242-6. doi: 10.1006/niox.2001.0396.
The implication of NO in many inflammatory diseases has been well documented. We have previously reported that some chalcone derivatives can control the iNOS pathway in inflammatory processes. In the present study, we have assessed the NO-scavenging capacity of three chalcone derivatives (CH8, CH11, and CH12) in a competitive assay with HbO(2), a well-known physiologically relevant NO scavenger. Our data identify these chalcones as new NO scavengers. The estimated second-order rate constants (k(s)) for the reaction of the three derivatives with NO is in the same range as the value obtained for HbO(2), with CH11 exerting the greatest effect. These results suggest an additional action of these compounds on NO regulation.
一氧化氮（NO）在许多炎症性疾病中的作用已有充分记录。我们之前曾报道，一些查尔酮衍生物可在炎症过程中控制诱导型一氧化氮合酶（iNOS）途径。在本研究中，我们在与HbO₂（一种著名的生理相关NO清除剂）的竞争性试验中评估了三种查尔酮衍生物（CH8、CH11和CH12）的NO清除能力。我们的数据将这些查尔酮鉴定为新的NO清除剂。三种衍生物与NO反应的估计二级速率常数（k(s)）与HbO₂所得值处于同一范围，其中CH11的作用最大。这些结果表明这些化合物在NO调节方面有额外作用。
