MacGlashan Donald, Gauvreau Gail, Schroeder John T
Johns Hopkins Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA.
Curr Allergy Asthma Rep. 2002 Mar;2(2):126-32. doi: 10.1007/s11882-002-0007-0.
The inflammatory response that is often associated with asthma is characterized by the recruitment of eosinophils, basophils, and lymphocytes. Until recently, profiling the basophil and defining its functional characteristics have been difficult. With the advent of some new tools, there is a steadily increasing body of information on the presence and potential activities of the basophil. Although the precise role of these cells in airway diseases, such as asthma, remain unclear, relatively accurate enumeration is now possible. Coupled with new insights into cytokine secretion from these cells, a more accurate picture of the dynamics of this specialized form of inflammation is available for refining our hypotheses regarding its regulation.
通常与哮喘相关的炎症反应的特征是嗜酸性粒细胞、嗜碱性粒细胞和淋巴细胞的募集。直到最近，对嗜碱性粒细胞进行分析并确定其功能特性一直很困难。随着一些新工具的出现，关于嗜碱性粒细胞的存在和潜在活性的信息正在稳步增加。尽管这些细胞在气道疾病（如哮喘）中的精确作用仍不清楚，但现在已经可以进行相对准确的计数。再加上对这些细胞分泌细胞因子的新认识，我们可以更准确地了解这种特殊炎症形式的动态，从而完善我们关于其调节的假设。
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