Ageenko A I, Chutkov N A
Vopr Onkol. 1975;21(9):62-5.
Cells of transplantable sarcomas primarily induced in hamsters with adenovirus, type 12, produced persistantly this virus in an infective form. In sera of sarcomabearing hamsters virus-neutrolizing antibodies and antibodies to T-antigen of tumors were revealed. The presence of T-antigen in cells of all types of sarcoma A-12 was demonstrated by means of immunofluorescence, as well as the absence of a specific luminescence of surface membranes of A-12 MML sarcoma cells, obtained from pulmonary micrometastases.
用12型腺病毒主要在仓鼠体内诱发的可移植肉瘤细胞持续产生感染形式的这种病毒。在患肉瘤的仓鼠血清中发现了病毒中和抗体以及肿瘤T抗原抗体。通过免疫荧光法证实了所有类型的A - 12肉瘤细胞中都存在T抗原,同时也证实了从肺微转移灶获得的A - 12 MML肉瘤细胞表面膜不存在特异性发光现象。