Geier Mark R, Geier David A
The Genetic Centers of America, Silver Spring, MD 20905-5726, USA.
Ann Pharmacother. 2002 Mar;36(3):370-4. doi: 10.1345/aph.1A304.
Recent studies have suggested that adult hepatitis B vaccination may be associated with adverse reactions.
To further examine the relative risk, percentage association, and statistical significance of arthritic, immunologic, and gastrointestinal adverse reactions reported after adult hepatitis B vaccination compared with control vaccines.
The Vaccine Adverse Events Reporting System (VAERS) database was analyzed for the incidence of adverse reactions after adult hepatitis B immunization compared with the incidence of adverse reactions reported to VAERS about vaccine control groups.
The medical and scientific communities have generally accepted that hepatitis B vaccine, a highly purified, genetically engineered single-antigen vaccine, is a safe vaccine.
The VAERS database was analyzed from 1997 to 2000 for adverse reactions associated with adult hepatitis B vaccination and from 1991 to 2000 for adverse reactions reported about vaccine control groups.
The results showed a statistically significant increase in the incidence of adverse reactions reported after adult hepatitis B vaccination when compared with the incidence of adverse reactions reported to VAERS about control vaccines.
Patients and physicians need to be fully informed of the potential adverse reactions associated with hepatitis B vaccination so that together they can make an informed consent decision about the risk versus the benefit. Patients who may have had an associated adverse reaction to hepatitis B vaccine should be made aware that they may be eligible for compensation from the no-fault Vaccine Compensation Act, administered by the US Court of Claims.
近期研究表明成人乙肝疫苗接种可能与不良反应有关。
进一步研究成人接种乙肝疫苗后报告的关节炎、免疫和胃肠道不良反应与对照疫苗相比的相对风险、关联百分比及统计学意义。
分析疫苗不良事件报告系统（VAERS）数据库中成人乙肝免疫后不良反应的发生率，并与向VAERS报告的疫苗对照组不良反应发生率进行比较。
医学界和科学界普遍认为，乙肝疫苗是一种高度纯化的基因工程单抗原疫苗，是一种安全的疫苗。
分析1997年至2000年VAERS数据库中与成人乙肝疫苗接种相关的不良反应，以及1991年至2000年报告的疫苗对照组不良反应。
结果显示，与向VAERS报告的对照疫苗不良反应发生率相比，成人接种乙肝疫苗后报告的不良反应发生率有统计学意义的增加。
患者和医生需要充分了解与乙肝疫苗接种相关的潜在不良反应，以便共同就是否接受疫苗接种做出明智的决定。可能对乙肝疫苗有相关不良反应的患者应意识到，他们可能有资格根据美国索赔法院管理的无过错疫苗赔偿法获得赔偿。
