Sapan Nihat, Nacarkucuk Ergun, Canitez Yakup, Saglam Halil
Division of Pediatric Allergy, Medical Faculty, Uludag University, Bursa, Turkey.
Pediatr Int. 2002 Apr;44(2):157-62. doi: 10.1046/j.1328-8067.2001.01528.x.
Recently, there was a great increase in allergic reactions to latex and this brought relatively more concern to the latex allergy. In this prospective study we aimed to identify the frequency of latex allergy in preoperative patients, and tried to clarify whether it is necessary to perform latex allergy tests routinely in the preoperative period or not.
A total of 188 children, aged 1-14, who were admitted for various operations, were randomly included in this study and of them, 181 completed the study. Latex specific history was taken from all patients. Latex skin prick tests, challenge tests with latex gloves, total IgE and latex specific IgE measurements were performed.
Of 181 children, two (1.1%) had positive latex skin prick tests. Latex challenge tests were negative in all children. Latex specific IgE was positive in 12 children (6.6%) as class II or higher, but no patient had allergic reactions in operations. History of repeated operations was a risk factor for latex sensitization. The risk was higher in the presence of both history of repeated operations and history of allergic disease. However, the risk was not higher in patients with the history of only allergic disease, compared to ones who had a history of neither repeated operations nor allergic disease.
We conclude that routine preoperative latex allergy tests seem to be not necessary because of no allergic reactions during operation in spite of the sensitization of 6.6% detected by latex specific IgE. However, this should be investigated in larger studies.
最近,对乳胶的过敏反应大幅增加,这使得乳胶过敏受到了更多关注。在这项前瞻性研究中,我们旨在确定术前患者中乳胶过敏的发生率,并试图阐明术前是否有必要常规进行乳胶过敏测试。
共有188名年龄在1至14岁之间因各种手术入院的儿童被随机纳入本研究,其中181名完成了研究。对所有患者进行了乳胶特异性病史采集。进行了乳胶皮肤点刺试验、乳胶手套激发试验、总IgE和乳胶特异性IgE测量。
181名儿童中,两名(1.1%)乳胶皮肤点刺试验呈阳性。所有儿童的乳胶激发试验均为阴性。12名儿童(6.6%)的乳胶特异性IgE呈II级或更高水平阳性,但没有患者在手术中出现过敏反应。重复手术史是乳胶致敏的一个危险因素。在既有重复手术史又有过敏疾病史的情况下,风险更高。然而,与既无重复手术史也无过敏疾病史的患者相比,仅有过敏疾病史的患者风险并不更高。
我们得出结论,尽管乳胶特异性IgE检测到6.6%的致敏率,但由于手术中未出现过敏反应,术前常规乳胶过敏测试似乎没有必要。然而,这应该在更大规模的研究中进行调查。