人类淋巴瘤中猿猴病毒40 DNA序列的存在。

Presence of simian virus 40 DNA sequences in human lymphomas.

作者信息

Shivapurkar Narayan, Harada Kenichi, Reddy Jyotsna, Scheuermann Richard H, Xu Yin, McKenna Robert W, Milchgrub Sara, Kroft Steven H, Feng Ziding, Gazdar Adi F

出版信息

Lancet. 2002 Mar 9;359(9309):851-2. doi: 10.1016/S0140-6736(02)07921-7.

DOI:10.1016/S0140-6736(02)07921-7

PMID:11897287

Abstract

Simian virus 40 (SV40)--a potent oncogenic virus--has been associated previously with some types of human tumours, but not with lymphomas. We examined human tumours for the presence of specific SV40 DNA sequences by PCR and Southern blotting. Viral sequences were present in 29 (43%) of 68 non-Hodgkin lymphomas, and in three (9%) of 31 of Hodgkin's lymphomas. Viral sequences were detected at low frequencies (about 5%) in 235 epithelial tumours of adult and paediatric origin, and were absent in 40 control tissues. Our data suggest that SV40 might be a cofactor in the pathogenesis of non-Hodgkin lymphomas.

摘要

猿猴病毒40（SV40）——一种强效致癌病毒——此前已与某些类型的人类肿瘤相关，但与淋巴瘤无关。我们通过聚合酶链反应（PCR）和Southern印迹法检测了人类肿瘤中特定SV40 DNA序列的存在情况。在68例非霍奇金淋巴瘤中有29例（43%）存在病毒序列，在31例霍奇金淋巴瘤中有3例（9%）存在病毒序列。在235例成人和儿童来源的上皮性肿瘤中，病毒序列的检出频率较低（约5%），而在40例对照组织中未检测到。我们的数据表明，SV40可能是非霍奇金淋巴瘤发病机制中的一个辅助因素。